2HEL Chain A
Ephrin type-A receptor 4 (EPHA4)
Inactive — 5.8%DFG-inαC-in
Resolution
2.35 Å
R-value
0.209
Predicted activity confidence5.8%
Structure info
Alternate conformation—
Missing atoms15
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AKEIDASCIKIEKVIGVGEFGEVCSGRLKVEICVAIKTLKYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSAVHRDLAARNILVNSNLVCKVSDFGMSRVKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSL
UniProt reference sequence
IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDK
Aligned reference sequence
IKIE----------------KVIGVGE----------------FGEVCSGRL--KVPGK---------------------------------REICVAIKTLK--AGYTDKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIHLEGVVTKCK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEYMEN--------------GSLDAFLRK--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTVIQLVGMLRGIGSGMKYLSDM---------------------------------------------SYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGMSRVLEDDPEA--AYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGGKIPIRWTAPEAIAY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MSNQDVIKAIEEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------IALHQLMLDCWQKERSDRPK--------------FGQIVNMLDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IKIE----------------KVIGVGE----------------FGEVCSGRL--KV-------------------------------------EICVAIKTLK----YTDKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIHLEGVVTKCK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEYMEN--------------GSLDAFLRK--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTVIQLVGMLRGIGSGMKYLSDM---------------------------------------------SAVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGMSRV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIPIRWTAPEAIAY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MSNQDVIKAIEEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------IALHQLMLDCWQKERSDRPK--------------FGQIVNMLDK
Activation segment
DFGMSRV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIPIRWTAPE
Binding pocket
KVIGVGEFGEVCSVAIKTLDFLSEASIMGQFDPNIIHLEGVMIITEYMENGSLDAFLRKYLSDMSAVHRDLAARNILVVSDFGMS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2HEL, Chain A