2F57 Chain A
Serine/threonine-protein kinase PAK 5 (PAK5)
Inactive — 45.7%DFG-inαC-in
Resolution
1.8 Å
R-value
0.155
Predicted activity confidence45.7%
Structure info
Alternate conformationA
Missing atoms20
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
NLYFQSMSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQ
UniProt reference sequence
LANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL
Aligned reference sequence
LANF----------------IKIGEGS----------------TGIVCIATE--KH------------------------------------TGKQVAVKKMD--LRKQQR----------------------------RELLFNEVVIMRDY--------------------------HHDNVVDMYSSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEFLEG--------------GALTDIVTH--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMNEEQIATVCLSVLRALSYLHNQ---------------------------------------------GVIHRDI-----KSDSILLTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRIKLSDFGFCAQVSKEVPK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLVGTPYWMAPEVISR--------------------------------LPYG-TEVDIWSLGIMVIEMIDG-----------------EPPYFN--------------------------------------------------EPPLQAMRRIRDS--LPPRVKDLHKVS---------------------------------------------------------------------------------------------------SVLRGFLDLMLVREPSQRAT--------------AQELLGHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LANF----------------IKIGEGS----------------TGIVCIATE--KH------------------------------------TGKQVAVKKMD--LRKQQR----------------------------RELLFNEVVIMRDY--------------------------HHDNVVDMYSSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEFLEG--------------GALTDIVTH--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMNEEQIATVCLSVLRALSYLHNQ---------------------------------------------GVIHRDI-----KSDSILLTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRIKLSDFGFCAQVSKEVPK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-LVGTPYWMAPEVISR--------------------------------LPYG-TEVDIWSLGIMVIEMIDG-----------------EPPYFN--------------------------------------------------EPPLQAMRRIRDS--LPPRVKDLHKVS---------------------------------------------------------------------------------------------------SVLRGFLDLMLVREPSQRAT--------------AQELLGHPFL
Activation segment
DFGFCAQVSKEVPK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-LVGTPYWMAPE
Binding pocket
IKIGEGSTGIVCIVAVKKMLLFNEVVIMRDYHDNVVDMYSSWVVMEFLEGGALTDIVTHYLHNQGVIHRDIKSDSILLLSDFGFC
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2F57, Chain A