2F2C Chain B
Cyclin-dependent kinase 6 (CDK6)
Active — 94.3%DFG-inαC-inType1 · AP9
Resolution
2.8 Å
R-value
0.241
Predicted activity confidence94.3%
Structure info
Alternate conformation—
Missing atoms27
Missing residues4
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ADQQYECAEIGGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPQAFAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER
UniProt reference sequence
YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
Aligned reference sequence
YECV----------------AEIGEGA----------------YGKVFKARD--LKN-----------------------------------GGRFVALKRVR--VQTGEEGM--------------------------PLSTIREVAVLRHL--ETF---------------------EHPNVVRLFDVCTVSR--TDRET-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTLVFEHVD---------------QDLTTYLDK--VPEP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPTETIKDMMFQLLRGLDFLHSH---------------------------------------------RVVHRDL-----KPQNILVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQIKLADFGLARIYSFQMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSVVVTLWYRAPEVLLQ--------------------------------SSYA-TPVDLWSVGCIFAEMFRR-----------------KPLFRG--------------------------------------------------SSDVDQLGKILDV--IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDID---------------------------------------------------------------------------ELGKDLLLKCLTFNPAKRIS--------------AYSALSHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEC-----------------AEIG--------------------GKVFKARD--LKN-----------------------------------GGRFVALKRVR--VQTGEEGM--------------------------PLSTIREVAVLRHL--ETF---------------------EHPNVVRLFDVCTVS---TDRET-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTLVFEHVD---------------QDLTTYLDK--VPEP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPTETIKDMMFQLLRGLDFLHSH---------------------------------------------RVVHRDL-----KPQNILVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQIKLADFGLARIYSFQMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSVVVTLWYRAPEVLLQ--------------------------------SSYA-TPVDLWSVGCIFAEMFRR-----------------KPLFRG--------------------------------------------------SSDVDQLGKILDV--IGLPGEEDWP-------QAF----AQPIEKFVTDID---------------------------------------------------------------------------ELGKDLLLKCLTFNPAKRIS--------------AYSALSHPYF
Activation segment
DFGLARIYSFQMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSVVVTLWYRAPE
Binding pocket
AEIG____GKVFKVALKRVSTIREVAVLRHLEPNVVRLFDVTLVFEHVD_QDLTTYLDKFLHSHRVVHRDLKPQNILVLADFGLA
Ligand info
Orthosteric ligand
AP9
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2F2C, Chain B