2DQ7 Chain X
Tyrosine-protein kinase Fyn (FYN)
Active — 99.8%DFG-inαC-inType1 · STU
Resolution
2.8 Å
R-value
0.255
Predicted activity confidence99.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNETARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY
UniProt reference sequence
LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLED
Aligned reference sequence
LQLI----------------KRLGNGQ----------------FGEVWMGTW--N-------------------------------------GNTKVAIKTLK--PGTMS-----------------------------PESFLEEAQIMKKL--------------------------KHDKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYMNK--------------GSLLDFLKD--GEGR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALKLPNLVDMAAQVAAGMAYIERM---------------------------------------------NYIHRDL-----RSANILVGN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLICKIADFGLARLIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGAKFPIKWTAPEAALY--------------------------------GRFT-IKSDVWSFGILLTELVTK--G--------------RVPYPG--------------------------------------------------MNNREVLEQVERG--YRMPCPQDCP-----------------------------------------------------------------------------------------------------ISLHELMIHCWKKDPEERPT--------------FEYLQSFLED
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LQLI----------------KRLGNGQ----------------FGEVWMGTW--N-------------------------------------GNTKVAIKTLK--PGTMS-----------------------------PESFLEEAQIMKKL--------------------------KHDKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYMNK--------------GSLLDFLKD--GEGR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALKLPNLVDMAAQVAAGMAYIERM---------------------------------------------NYIHRDL-----RSANILVGN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLICKIADFGLARLIEDNE-T--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGAKFPIKWTAPEAALY--------------------------------GRFT-IKSDVWSFGILLTELVTK--G--------------RVPYPG--------------------------------------------------MNNREVLEQVERG--YRMPCPQDCP-----------------------------------------------------------------------------------------------------ISLHELMIHCWKKDPEERPT--------------FEYLQSFLED
Activation segment
DFGLARLIEDNE-T--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGAKFPIKWTAPE
Binding pocket
KRLGNGQFGEVWMVAIKTLSFLEEAQIMKKLKDKLVQLYAVYIVTEYMNKGSLLDFLKDYIERMNYIHRDLRSANILVIADFGLA
Ligand info
Orthosteric ligand
STU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2DQ7, Chain X