2CMW Chain A
Casein kinase I isoform gamma-1 (CSNK1G1)
Active — 100.0%DFG-inαC-inType1,Allosteric,Allosteric · OLP
Resolution
1.75 Å
R-value
0.167
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGS
UniProt reference sequence
FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTD
Aligned reference sequence
FRVG----------------KKIGCGN----------------FGELRLGKN--LY------------------------------------TNEYVAIKLEP--IKSR------------------------------APQLHLEYRFYKQL--GS----------------------AGEGLPQVYYFGPCGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNAMVLELLG---------------PSLEDLFDL--CDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTLKTVLMIAIQLLSRMEYVHSK---------------------------------------------NLIYRDV-----KPENFLIGR--QGNKK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHVIHIIDFGLAKEYIDPETK--KHIPYREH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLTGTARYMSINTHLG--------------------------------KEQS-RRDDLEALGHMFMYFLRG-----------------SLPWQG--LKADTLK-----------------------------------------ERYQKIGDTKRNT--PIEALCENFP-----------------------------------------------------------------------------------------------------EEMATYLRYVRRLDFFEKPD--------------YEYLRTLFTD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
MRVG----------------KKIGCGN----------------FGELRLGKN--LY------------------------------------TNEYVAIKLEP--IKSR------------------------------APQLHLEYRFYKQL--GS----------------------AGEGLPQVYYFGP-GK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNAMVLELLG---------------PSLEDLFDL--CDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTLKTVLMIAIQLLSRMEYVHSK---------------------------------------------NLIYRDV-----KPENFLIGR--QGNKK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHVIHIIDFGLAKEYIDPETK--KHIPYREH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSL-GTARYMSINTHLG--------------------------------KEQS-RRDDLEALGHMFMYFLRG-----------------SLPWQG--LKADTLK-----------------------------------------ERYQKIGDTKRNT--PIEALCENFP-----------------------------------------------------------------------------------------------------EEMATYLRYVRRLDFFEKPD--------------YEYLRTLFTD
Activation segment
DFGLAKEYIDPETK--KHIPYREH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSL-GTARYMSIN
Binding pocket
KKIGCGNFGELRLVAIKLEQLHLEYRFYKQLGEGLPQVYYFAMVLELLG_PSLEDLFDLYVHSKNLIYRDVKPENFLIIIDFGLA
Ligand info
Orthosteric ligand
OLP
Allosteric ligand
OLP
Ligand typeType1,Allosteric,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2CMW, Chain A