2C6D Chain A
Aurora kinase A (AURKA)
Inactive — 0.0%DFG-inαC-inATPlike · ANP
Resolution
2.2 Å
R-value
0.23
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms21
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKP
UniProt reference sequence
FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
Aligned reference sequence
FEIG----------------RPLGKGK----------------FGNVYLARE--KQ------------------------------------SKFILALKVLF--KAQLEKAGV-------------------------EHQLRREVEIQSHL--------------------------RHPNILRLYGYFHDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPL--------------GTVYRELQK--LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK---------------------------------------------RVIHRDI-----KPENLLLGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGELKIADFGWSVHAPSSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTLCGTLDYLPPEMIEG--------------------------------RMHD-EKVDLWSLGVLCYEFLVG-----------------KPPFEA--------------------------------------------------NTYQETYKRISRV--EFTFPDFVT------------------------------------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM--------------LREVLEHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEIG----------------RPLGKGK----------------FGNVYLARE--KQ------------------------------------SKFILALKVLF--KAQLEKAGV-------------------------EHQLRREVEIQSHL--------------------------RHPNILRLYGYFHDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPL--------------GTVYRELQK--LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK---------------------------------------------RVIHRDI-----KPENLLLGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGELKIADFGWSVH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLDYLPPEMIEG--------------------------------RMHD-EKVDLWSLGVLCYEFLVG-----------------KPPFEA--------------------------------------------------NTYQETYKRISRV--EFTFPDFVT------------------------------------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM--------------LREVLEHPWI
Activation segment
DFGWSVH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLDYLPPE
Binding pocket
RPLGKGKFGNVYLLALKVLQLRREVEIQSHLRPNILRLYGYYLILEYAPLGTVYRELQKYCHSKRVIHRDIKPENLLLIADFGWS
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2C6D, Chain A