2C47 Chain B
Casein kinase I isoform gamma-2 (CSNK1G2)
Active — 99.6%DFG-inαC-inType1 · 5ID
Resolution
2.4 Å
R-value
0.211
Predicted activity confidence99.6%
Structure info
Alternate conformationA
Missing atoms10
Missing residues5
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PNFRVGKKIGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPI
UniProt reference sequence
FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTD
Aligned reference sequence
FRVG----------------KKIGCGN----------------FGELRLGKN--LY------------------------------------TNEYVAIKLEP--IKSR------------------------------APQLHLEYRFYKQL--S-----------------------ATEGVPQVYYFGPCGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNAMVLELLG---------------PSLEDLFDL--CDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTLKTVLMIAIQLITRMEYVHTK---------------------------------------------SLIYRDV-----KPENFLVGR--PGTKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QHAIHIIDFGLAKEYIDPETK--KHIPYREH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLTGTARYMSINTHLG--------------------------------KEQS-RRDDLEALGHMFMYFLRG-----------------SLPWQG--LKADTLK-----------------------------------------ERYQKIGDTKRAT--PIEVLCENFP-----------------------------------------------------------------------------------------------------EEMATYLRYVRRLDFFEKPD--------------YDYLRKLFTD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FRVG----------------KKI---------------------GELRLGKN--LY------------------------------------TNEYVAIKLEP--IKSR------------------------------APQLHLEYRFYKQL--S-----------------------ATEGVPQVYYFGP-GK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNAMVLELLG---------------PSLEDLFDL--CDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTLKTVLMIAIQLITRMEYVHTK---------------------------------------------SLIYRDV-----KPENFLVGR--PGTKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QHAIHIIDFGLAKEYIDPETK--KHIPYREH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLTGTARYMSINTHLG--------------------------------KEQS-RRDDLEALGHMFMYFLRG-----------------SLPWQG--LKADTLK-----------------------------------------ERYQKIGDTKRAT--PIEVLCENFP-----------------------------------------------------------------------------------------------------EEMATYLRYVRRLDFFEKPD--------------YDYLRKLFTD
Activation segment
DFGLAKEYIDPETK--KHIPYREH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLTGTARYMSIN
Binding pocket
KKIG_____ELRLVAIKLEQLHLEYRFYKQLSEGVPQVYYFAMVLELLG_PSLEDLFDLYVHTKSLIYRDVKPENFLVIIDFGLA
Ligand info
Orthosteric ligand
5ID
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2C47, Chain B