2C30 Chain A
Serine/threonine-protein kinase PAK 6 (PAK6)
Active — 99.9%DFG-inαC-in
Resolution
1.6 Å
R-value
0.198
Predicted activity confidence99.9%
Structure info
Alternate conformationA
Missing atoms11
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLY
UniProt reference sequence
LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL
Aligned reference sequence
LDSY----------------VKIGEGS----------------TGIVCLARE--KH------------------------------------SGRQVAVKMMD--LRKQQR----------------------------RELLFNEVVIMRDY--------------------------QHFNVVEMYKSYLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVLMEFLQG--------------GALTDIVSQ--V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLNEEQIATVCEAVLQALAYLHAQ---------------------------------------------GVIHRDI-----KSDSILLTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRVKLSDFGFCAQISKDVPK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLVGTPYWMAPEVISR--------------------------------SLYA-TEVDIWSLGIMVIEMVDG-----------------EPPYFS--------------------------------------------------DSPVQAMKRLRDS--PPPKLKNSHKVS---------------------------------------------------------------------------------------------------PVLRDFLERMLVRDPQERAT--------------AQELLDHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LDSY----------------VKIGEGS----------------TGIVCLARE--KH------------------------------------SGRQVAVKMMD--LRKQQR----------------------------RELLFNEVVIMRDY--------------------------QHFNVVEMYKSYLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVLMEFLQG--------------GALTDIVSQ--V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLNEEQIATVCEAVLQALAYLHAQ---------------------------------------------GVIHRDI-----KSDSILLTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRVKLSDFGFCAQISKDVPK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-LVGTPYWMAPEVISR--------------------------------SLYA-TEVDIWSLGIMVIEMVDG-----------------EPPYFS--------------------------------------------------DSPVQAMKRLRDS--PPPKLKNSHKVS---------------------------------------------------------------------------------------------------PVLRDFLERMLVRDPQERAT--------------AQELLDHPFL
Activation segment
DFGFCAQISKDVPK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-LVGTPYWMAPE
Binding pocket
VKIGEGSTGIVCLVAVKMMLLFNEVVIMRDYQFNVVEMYKSWVLMEFLQGGALTDIVSQYLHAQGVIHRDIKSDSILLLSDFGFC
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2C30, Chain A