2BVA Chain B
Serine/threonine-protein kinase PAK 4 (PAK4)
Active — 92.8%DFG-inαC-in
Resolution
2.3 Å
R-value
0.192
Predicted activity confidence92.8%
Structure info
Alternate conformation—
Missing atoms7
Missing residues3
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGIVCIATVRSSGKLVAVKKMDLLLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVEVPRRKLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQ
UniProt reference sequence
LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
Aligned reference sequence
LDNF----------------IKIGEGS----------------TGIVCIATV--RS------------------------------------SGKLVAVKKMD--LRKQQR----------------------------RELLFNEVVIMRDY--------------------------QHENVVEMYNSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEFLEG--------------GALTDIVTH--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMNEEQIAAVCLAVLQALSVLHAQ---------------------------------------------GVIHRDI-----KSDSILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRVKLSDFGFCAQVSKEVPR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSLVGTPYWMAPELISR--------------------------------LPYG-PEVDIWSLGIMVIEMVDG-----------------EPPYFN--------------------------------------------------EPPLKAMKMIRDN--LPPRLKNLHKVS---------------------------------------------------------------------------------------------------PSLKGFLDRLLVRDPAQRAT--------------AAELLKHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LDNF----------------IKIGE-------------------GIVCIATV--RS------------------------------------SGKLVAVKKMD--L-----------------------------------LLFNEVVIMRDY--------------------------QHENVVEMYNSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEFLEG--------------GALTDIVTH--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMNEEQIAAVCLAVLQALSVLHAQ---------------------------------------------GVIHRDI-----KSDSILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGRVKLSDFGFCAQV--EVPR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-LVGTPYWMAPELISR--------------------------------LPYG-PEVDIWSLGIMVIEMVDG-----------------EPPYFN--------------------------------------------------EPPLKAMKMIRDN--LPPRLKNLHKVS---------------------------------------------------------------------------------------------------PSLKGFLDRLLVRDPAQRAT--------------AAELLKHPFL
Activation segment
DFGFCAQV--EVPR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-LVGTPYWMAPE
Binding pocket
IKIGEG___IVCIVAVKKMLLFNEVVIMRDYQENVVEMYNSWVVMEFLEGGALTDIVTHVLHAQGVIHRDIKSDSILLLSDFGFC
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2BVA, Chain B