2BUJ Chain A
Serine/threonine-protein kinase 16 (STK16)
Inactive — 11.0%DFG-inαC-inType1,Allosteric · STU
Resolution
2.6 Å
R-value
0.187
Predicted activity confidence11.0%
Structure info
Alternate conformation—
Missing atoms12
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
NLYFQGHMVIIDNKHYLFIQKLGEFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPG
UniProt reference sequence
YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEA
Aligned reference sequence
YLFI----------------QKLGEGG----------------FSYVDLVEG--LH------------------------------------DGHFYALKRIL--CHEQQD----------------------------REEAQREADMHRLF--------------------------NHPNILRLVAYCLRER--GAKH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAWLLLPFFKR--------------GTLWNEIER--LKDKGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLTEDQILWLLLGICRGLEAIHAK---------------------------------------------GYAHRDL-----KPTNILLGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGQPVLMDLGSMNQACIHVEG--SRQALTLQDW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAQRCTISYRAPELFSV--QSH---------------------------CVID-ERTDVWSLGCVLYAMMFG-----------------EGPYDM--VF----------------------------------------------QKGDSVALAVQNQ--LSIPQSPRHS-----------------------------------------------------------------------------------------------------SALRQLLNSMMTVDPHQRPH--------------IPLLLSQLEA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YLFI----------------QKLGE------------------FSYVDLVEG--LH------------------------------------DGHFYALKRIL--CHEQQD----------------------------REEAQREADMHRLF--------------------------NHPNILRLVAYCLRER--GAKH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAWLLLPFFKR--------------GTLWNEIER--LKDKGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLTEDQILWLLLGICRGLEAIHAK---------------------------------------------GYAHRDL-----KPTNILLGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGQPVLMDLGSMNQACIHVEG--SRQALTLQDW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAQRCTISYRAPELFSV--QSH---------------------------CVID-ERTDVWSLGCVLYAMMFG-----------------EGPYDM--VF----------------------------------------------QKGDSVALAVQNQ----IPQSPRHS-----------------------------------------------------------------------------------------------------SALWQLLNSMMTVDPHQRPH--------------IPLLLSQLEA
Activation segment
DLGSMNQACIHVEG--SRQALTLQDW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAQRCTISYRAPE
Binding pocket
QKLGE__FSYVDLYALKRIEAQREADMHRLFNPNILRLVAYWLLLPFFKRGTLWNEIERAIHAKGYAHRDLKPTNILLLMDLGSM
Ligand info
Orthosteric ligand
STU
Allosteric ligand
STU
Ligand typeType1,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2BUJ, Chain A