2AUH Chain A
Insulin receptor (INSR)
Active — 76.5%DFG-inαC-in
Resolution
3.2 Å
R-value
0.223
Predicted activity confidence76.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
YVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIETDRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK
UniProt reference sequence
ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD
Aligned reference sequence
ITLL----------------RELGQGS----------------FGMVYEGNA--RDIIKGE-------------------------------AETRVAVKTVN--ESASLRE---------------------------RIEFLNEASVMKGF--------------------------TCHHVVRLLGVVSKGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVVMELMAH--------------GDLKSYLRS--LRPEAENNPGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPTLQEMIQMAAEIADGMAYLNAK---------------------------------------------KFVHRDL-----AARNCMVAH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMTRDIYETDYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGLLPVRWMAPESLKD--------------------------------GVFT-TSSDMWSFGVVLWEITSL--A--------------EQPYQG--------------------------------------------------LSNEQVLKFVMDG--GYLDQPDNCP-----------------------------------------------------------------------------------------------------ERVTDLMRMCWQFNPKMRPT--------------FLEIVNLLKD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLL----------------RELGQGS----------------FGMVYEGNA--RDIIKGE-------------------------------AETRVAVKTVN--ESASLRE---------------------------RIEFLNEASVMKGF--------------------------TCHHVVRLLGVVSKGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVVMELMAH--------------GDLKSYLRS--LRPEAENNPGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPTLQEMIQMAAEIADGMAYLNAK---------------------------------------------KFVHRDL-----AARNCMVAH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMTRDI-ETD----RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGLLPVRWMAPESLKD--------------------------------GVFT-TSSDMWSFGVVLWEITSL--A--------------EQPYQG--------------------------------------------------LSNEQVLKFVMDG--GYLDQPDNCP-----------------------------------------------------------------------------------------------------ERVTDLMRMCWQFNPNMRPT--------------FLEIVNLLKD
Activation segment
DFGMTRDI-ETD----RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGLLPVRWMAPE
Binding pocket
RELGQGSFGMVYEVAVKTVEFLNEASVMKGFT_HVVRLLGVLVVMELMAHGDLKSYLRSYLNAKKFVHRDLAARNCMVIGDFGMT
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2AUH, Chain A