2ACX Chain A
G protein-coupled receptor kinase 6 (GRK6)
Active — 99.9%DFG-inαC-inATPlike · ANP
Resolution
2.6 Å
R-value
0.204
Predicted activity confidence99.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KARKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERNPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRNLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGS
UniProt reference sequence
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF
Aligned reference sequence
FRQY----------------RVLGKGG----------------FGEVCACQV--RA------------------------------------TGKMYACKKLE--KKRIKKRKG-------------------------EAMALNEKQILEKV--------------------------NSRFVVSLAYAYETKD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALCLVLTLMNG--------------GDLKFHIYH--MGQA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFPEARAVFYAAEICCGLEDLHRE---------------------------------------------RIVYRDL-----KPENILLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGHIRISDLGLAVHVPEGQTI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGRVGTVGYMAPEVVKN--------------------------------ERYT-FSPDWWALGCLLYEMIAG-----------------QSPFQQ--RKKK--------------------------------------------IKREEVERLVKEV--PEEYSERFS------------------------------------------------------------------------------------------------------PQARSLCSQLLCKDPAERLG--CRGGS-------AREVKEHPLF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FRQY----------------RVLGKGG----------------FGEVCACQV--RA------------------------------------TGKMYACKKLE--KKRIKKRKG-------------------------EAMALNEKQILEKV--------------------------NSRFVVSLAYAYETKD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALCLVLTLMNG--------------GDLKFHIYH--MGQA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFPEARAVFYAAEICCGLEDLHRE---------------------------------------------RIVYRDL-----KPENILLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGHIRISDLGLAVHVPEGQTI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGRVGTVGYMAPEVVKN--------------------------------ERYT-FSPDWWALGCLLYEMIAG-----------------QSPFQQ--RKKK--------------------------------------------IKREEVERLVKEV--PEEYSERFS------------------------------------------------------------------------------------------------------PQARSLCSQLLCKDPAERLG--CRGGS-------AREVKEHPLF
Activation segment
DLGLAVHVPEGQTI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGRVGTVGYMAPE
Binding pocket
RVLGKGGFGEVCAYACKKLMALNEKQILEKVNRFVVSLAYACLVLTLMNGGDLKFHIYHDLHRERIVYRDLKPENILLISDLGLA
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2ACX, Chain A