2AC3 Chain A
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)
Inactive — 0.2%DFG-outαC-out
Resolution
2.1 Å
R-value
0.254
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GSTDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ
UniProt reference sequence
YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV
Aligned reference sequence
YQLQ--E-------------DVLGEGA----------------HARVQTCIN--LI------------------------------------TSQEYAVKIIE--KQPGHI----------------------------RSRVFREVEMLYQC--Q-----------------------GHRNVLELIEFFEEED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFYLVFEKMRG--------------GSILSHIHK--RR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFNELEASVVVQDVASALDFLHNK---------------------------------------------GIAHRDL-----KPENILCEH--PNQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSPVKICDFDLGSGIKLNGDC--SPISTPEL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPCGSAEYMAPEVVEA--FSEEA-------------------------SIYD-KRCDLWSLGVILYILLSG-----------------YPPFVG--RCGSDCGWDRGEACP---------------------------------ACQNMLFESIQEG--KYEFPDKDWAHIS--------------------------------------------------------------------------------------------------CAAKDLISKLLVRDAKQRLS--------------AAQVLQHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLQ--E-------------DVLGEGA----------------HARVQTCIN--LI------------------------------------TSQEYAVKIIE--KQPGHI----------------------------RSRVFREVEMLYQC--Q-----------------------GHRNVLELIEFFEEED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFYLVFEKMRG--------------GSILSHIHK--RR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFNELEASVVVQDVASALDFLHNK---------------------------------------------GIAHRDL-----KPENILCEH--PNQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSPVKICDFDLGS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGSAEYMAPEVVEA--FSEEA-------------------------SIYD-KRCDLWSLGVILYILLSG-----------------YPPFVG--RCGSDCGW----ACP---------------------------------ACQNMLFESIQEG--KYEFPDKDWAHIS--------------------------------------------------------------------------------------------------CAAKDLISKLLVRDAKQRLS--------------AAQVLQHPWV
Activation segment
DFDLGS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGSAEYMAPE
Binding pocket
DVLGEGAHARVQTYAVKIIRVFREVEMLYQCQRNVLELIEFYLVFEKMRGGSILSHIHKFLHNKGIAHRDLKPENILCICDFDLG
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2AC3, Chain A