2A19 Chain C
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)
Inactive — 0.2%DFG-inαC-inATPlike · ANP
Resolution
2.5 Å
R-value
0.234
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms8
Missing residues6
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
HTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSKTKCLFIQMEFCDKGTLLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVGKEVDLYALGLILAELLGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKK
UniProt reference sequence
FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV
Aligned reference sequence
FKEI----------------ELIGSGG----------------FGQVFKAKH--RI------------------------------------DGKTYVIKRVK--YN--------------------------------NEKAEREVKALAKL--------------------------DHVNIVHYNGCWDGFD--YDPETSDDSLESSDYDPENSKNSSRSKTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLFIQMEFCDK--------------GTLEQWIEK--RRGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK---------------------------------------------KLIHRDL-----KPSNIFLVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQVKIGDFGLVTSLKNDGKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRSKGTLRYMSPEQISS--------------------------------QDYG-KEVDLYALGLILAELLHV-------------------------CDTA--------------------------------------------FETSKFFTDLRDG--IISDIFD--------------------------------------------------------------------------------------------------------KKEKTLLQKLLSKKPEDRPN--------------TSEILRTLTV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKEI----------------ELIGSGG----------------FGQVFKAKH--RI------------------------------------DGKTYVIKRVK--YN--------------------------------NEKAEREVKALAKL--------------------------DHVNIVHYNGCWDGFD--YDPET--------------------SKTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLFIQMEFCDK--------------GTL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LALELFEQITKGVDYIHSK---------------------------------------------KLINRDL-----KPSNIFLVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQVKIGDFGLV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-KEVDLYALGLILAELL---------------------------------------------------------------------------------------G--IISDIFD--------------------------------------------------------------------------------------------------------KKEKTLLQKLLSKKPEDRPN--------------TSEILRTLTV
Activation segment
DFGLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Binding pocket
ELIGSGGFGQVFKYVIKRVKAEREVKALAKLDVNIVHYNGCFIQMEFCDKGTL______YIHSKKLINRDLKPSNIFLIGDFGLV
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2A19, Chain C