2A19 Chain B
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)
Active — 99.4%DFG-inαC-inATPlike · ANP
Resolution
2.5 Å
R-value
0.234
Predicted activity confidence99.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AHTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKK
UniProt reference sequence
FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV
Aligned reference sequence
FKEI----------------ELIGSGG----------------FGQVFKAKH--RI------------------------------------DGKTYVIKRVK--YN--------------------------------NEKAEREVKALAKL--------------------------DHVNIVHYNGCWDGFD--YDPETSDDSLESSDYDPENSKNSSRSKTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLFIQMEFCDK--------------GTLEQWIEK--RRGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK---------------------------------------------KLIHRDL-----KPSNIFLVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQVKIGDFGLVTSLKNDGKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRSKGTLRYMSPEQISS--------------------------------QDYG-KEVDLYALGLILAELLHV-------------------------CDTA--------------------------------------------FETSKFFTDLRDG--IISDIFD--------------------------------------------------------------------------------------------------------KKEKTLLQKLLSKKPEDRPN--------------TSEILRTLTV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKEI----------------ELIGSGG----------------FGQVFKAKH--RI------------------------------------DGKTYVIKRVK--YN--------------------------------NEKAEREVKALAKL--------------------------DHVNIVHYNGCWDGFD--YD----------------------RSKTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLFIQMEFCDK--------------GTLEQWIEK--RRGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK---------------------------------------------KLINRDL-----KPSNIFLVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQVKIGDFGLVTSLKNDGKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKGTLRYMSPEQISS--------------------------------QDYG-KEVDLYALGLILAELLHV-------------------------CDTA--------------------------------------------FETSKFFTDLRDG--IISDIFD--------------------------------------------------------------------------------------------------------KKEKTLLQKLLSKKPEDRPN--------------TSEILRTLTV
Activation segment
DFGLVTSLKNDGKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSKGTLRYMSPE
Binding pocket
ELIGSGGFGQVFKYVIKRVKAEREVKALAKLDVNIVHYNGCFIQMEFCDKGTLEQWIEKYIHSKKLINRDLKPSNIFLIGDFGLV
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 2A19, Chain B