1ZRZ Chain A
Protein kinase C iota type (PRKCI)
Active — 99.3%DFG-inαC-inType1 · BI1
Resolution
3.0 Å
R-value
0.249
Predicted activity confidence99.3%
Structure info
Alternate conformation—
Missing atoms10
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDQNTEDYLFQVILEKQIRIPRSMSVKAASVLKSFLNKDPKERLGCLPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPVQLPDDDDIVRKIDQSEFEGFEYINPL
UniProt reference sequence
FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF
Aligned reference sequence
FDLL----------------RVIGRGS----------------YAKVLLVRL--KK------------------------------------TDRIYAMKVVK--KELVNDDED-------------------------IDWVQTEKHVFEQA--S-----------------------NHPFLVGLHSCFQTES--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLFFVIEYVNG--------------GDLMFHMQR--QR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPEEHARFYSAEISLALNYLHER---------------------------------------------GIIYRDL-----KLDNVLLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDYGMCKEGLRPGDT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STFCGTPNYIAPEILRG--------------------------------EDYG-FSVDWWALGVLMFEMMAG-----------------RSPFDI--VGSSDNPDQ---------------------------------------NTEDYLFQVILEK--QIRIPRSLS------------------------------------------------------------------------------------------------------VKAASVLKSFLNKDPKERLG--CHPQTG------FADIQGHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDLL----------------RVIGRGS----------------YAKVLLVRL--KK------------------------------------TDRIYAMKVVK--KELVNDDED-------------------------IDWVQTEKHVFEQA--S-----------------------NHPFLVGLHSCFQTES--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLFFVIEYVNG--------------GDLMFHMQR--QR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPEEHARFYSAEISLALNYLHER---------------------------------------------GIIYRDL-----KLDNVLLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKLTDYGMCKEGLRPGDT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-FCGTPNYIAPEILRG--------------------------------EDYG-FSVDWWALGVLMFEMMAG-----------------RSPF-----------DQ---------------------------------------NTEDYLFQVILEK--QIRIPRSMS------------------------------------------------------------------------------------------------------VKAASVLKSFLNKDPKERLG--CLPQTG------FADIQGHPFF
Activation segment
DYGMCKEGLRPGDT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-FCGTPNYIAPE
Binding pocket
RVIGRGSYAKVLLYAMKVVWVQTEKHVFEQASPFLVGLHSCFFVIEYVNGGDLMFHMQRYLHERGIIYRDLKLDNVLLLTDYGMC
Ligand info
Orthosteric ligand
BI1
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1ZRZ, Chain A