1YOJ Chain A
Proto-oncogene tyrosine-protein kinase Src (SRC)
Inactive — 0.2%DFG-outαC-out
Resolution
1.95 Å
R-value
0.216
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms9
Missing residues15
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
EIPRESLRLEVKLGQGGEVWMGTWNGTTRVAIKTLMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVAPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
UniProt reference sequence
LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED
Aligned reference sequence
LRLE----------------VKLGQGC----------------FGEVWMGTW--N-------------------------------------GTTRVAIKTLK--PGTMS-----------------------------PEAFLQEAQVMKKL--------------------------RHEKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYMSK--------------GSLLDFLKG--ETGK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLRLPQLVDMAAQIASGMAYVERM---------------------------------------------NYVHRDL-----RAANILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVADFGLARLIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGAKFPIKWTAPEAALY--------------------------------GRFT-IKSDVWSFGILLTELTTK--G--------------RVPYPG--------------------------------------------------MVNREVLDQVERG--YRMPCPPECP-----------------------------------------------------------------------------------------------------ESLHDLMCQCWRKEPEERPT--------------FEYLQAFLED
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRLE----------------VKLGQG------------------GEVWMGTW--N-------------------------------------GTTRVAIKTL-----------------------------------------------MKKL--------------------------RHEKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYMNK--------------GSLLDFLKG--ETGK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLRLPQLVDMSAQIASGMAYVERM---------------------------------------------NYVHRDL-----RAANILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIKWTAPEAALY--------------------------------GRFT-IKSDVWSFGILLTELTTK--G--------------RVPYPG--------------------------------------------------MVNREVLDQVERG--YRMPCPPECP-----------------------------------------------------------------------------------------------------ESLHDLMCQCWRKEPEERPT--------------FEYLQAFLED
Activation segment
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIKWTAPE
Binding pocket
VKLGQG__GEVWMVAIKTL________MKKLREKLVQLYAVYIVTEYMNKGSLLDFLKGYVERMNYVHRDLRAANILVVA_____
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1YOJ, Chain A