1XJD Chain A
Protein kinase C theta type (PRKCQ)
Active — 99.3%DFG-inαC-inType1 · STU
Resolution
2.0 Å
R-value
0.201
Predicted activity confidence99.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
IEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPQNMFRNFF
UniProt reference sequence
FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLF
Aligned reference sequence
FILH----------------KMLGKGS----------------FGKVFLAEF--KK------------------------------------TNQFFAIKALK--KDVVLMDDD-------------------------VECTMVEKRVLSLA--W-----------------------EHPFLTHMFCTFQTKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLFFVMEYLNG--------------GDLMYHIQS--CH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK---------------------------------------------GIVYRDL-----KLDNILLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKIADFGMCKENMLGDAK--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFCGTPDYIAPEILLG--------------------------------QKYN-HSVDWWSFGVLLYEMLIG-----------------QSPFHG--------------------------------------------------QDEEELFHSIRMD--NPFYPRWLE------------------------------------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG--V-----------RGDIRQHPLF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FILH----------------KMLGKGS----------------FGKVFLAEF--KK------------------------------------TNQFFAIKALK--KDVVLMDDD-------------------------VECTMVEKRVLSLA--W-----------------------EHPFLTHMFCTFQTKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLFFVMEYLNG--------------GDLMYHIQS--CH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK---------------------------------------------GIVYRDL-----KLDNILLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKIADFGMCKENMLGDAK--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FCGTPDYIAPEILLG--------------------------------QKYN-HSVDWWSFGVLLYEMLIG-----------------QSPFHG--------------------------------------------------QDEEELFHSIRMD--NPFYPRWLE------------------------------------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG--V-----------RGDIRQHPLF
Activation segment
DFGMCKENMLGDAK--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FCGTPDYIAPE
Binding pocket
KMLGKGSFGKVFLFAIKALCTMVEKRVLSLAWPFLTHMFCTFFVMEYLNGGDLMYHIQSFLHSKGIVYRDLKLDNILLIADFGMC
Ligand info
Orthosteric ligand
STU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1XJD, Chain A