1WCC Chain A
Cyclin-dependent kinase 2 (CDK2)
Inactive — 0.1%DFG-inαC-outType1 · CIG
Resolution
2.2 Å
R-value
0.181
Predicted activity confidence0.1%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRTEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
UniProt reference sequence
FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
Aligned reference sequence
FQKV----------------EKIGEGT----------------YGVVYKARN--KL------------------------------------TGEVVALKKIR--LDTETEGV--------------------------PSTAIREISLLKEL--------------------------NHPNIVKLLDVIHTEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLVFEFLH---------------QDLKKFMDA--SALT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH---------------------------------------------RVLHRDL-----KPQNLLINT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAIKLADFGLARAFGVPVRT--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRAPEILLG--C-----------------------------KYYS-TAVDIWSLGCIFAEMVTR-----------------RALFPG--------------------------------------------------DSEIDQLFRIFRT--LGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD------------------------------------------------------------------------EDGRSLLSQMLHYDPNKRIS--------------AKAALAHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FQKV----------------EKIGEGT----------------YGVVYKARN--KL------------------------------------TGEVVALKKIR------TEGV--------------------------PSTAIREISLLKEL--------------------------NHPNIVKLLDVIHTEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLVFEFLH---------------QDLKKFMDA--SALT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH---------------------------------------------RVLHRDL-----KPQNLLINT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAIKLADFGLARAF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTLWYRAPEILLG--C-----------------------------KYYS-TAVDIWSLGCIFAEMVTR-----------------RALFPG--------------------------------------------------DSEIDQLFRIFRT--LGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD------------------------------------------------------------------------EDGRSLLSQMLHYDPNKRIS--------------AKAALAHPFF
Activation segment
DFGLARAF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTLWYRAPE
Binding pocket
EKIGEGTYGVVYKVALKKITAIREISLLKELNPNIVKLLDVYLVFEFLH_QDLKKFMDAFCHSHRVLHRDLKPQNLLILADFGLA
Ligand info
Orthosteric ligand
CIG
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1WCC, Chain A