1VZO Chain A
Ribosomal protein S6 kinase alpha-5 (RPS6KA5)
Inactive — 0.0%DFG-inαC-out
Resolution
1.8 Å
R-value
0.208
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIVRGGDDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDV
UniProt reference sequence
FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF
Aligned reference sequence
FELL----------------KVLGTGA----------------YGKVFLVRK--ISGHD---------------------------------TGKLYAMKVLK--KATIVQKAKT------------------------TEHTRTERQVLEHI--R-----------------------QSPFLVTLHYAFQTET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLHLILDYING--------------GELFTHLSQ--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTEHEVQIYVGEIVLALEHLHKL---------------------------------------------GIIYRDI-----KLENILLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGHVVLTDFGLSKEFVADETE--RA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSFCGTIEYMAPDIVRG--GD----------------------------SGHD-KAVDWWSLGVLMYELLTG-----------------ASPFTV--DGEK--------------------------------------------NSQAEISRRILKS--EPPYPQEMS------------------------------------------------------------------------------------------------------ALAKDLIQRLLMKDPKKRLG--CGPRD-------ADEIKEHLFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELL----------------KVLGTGA----------------YGKVFLVRK--ISGHD---------------------------------TGKLYAMKVLK--KATIVQKAKT------------------------TEHTRTERQVLEHI--R-----------------------QSPFLVTLHYAFQTET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLHLILDYING--------------GELFTHLSQ--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFTEHEVQIYVGEIVLALEHLHKL---------------------------------------------GIIYRDI-----KLENILLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGHVVLTDFGLSKEFVADETE--RA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YDFCGTIEYMAPDIVRG--GD-------------------------------D-KAVDWWSLGVLMYELLTG-----------------ASPFTV--DGEK--------------------------------------------NSQAEISRRILKS--EPPYPQEMS------------------------------------------------------------------------------------------------------ALAKDLIQRLLMKDPKKRLG--CGPRD-------ADEIKEHLFF
Activation segment
DFGLSKEFVADETE--RA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YDFCGTIEYMAPD
Binding pocket
KVLGTGAYGKVFLYAMKVLHTRTERQVLEHIRPFLVTLHYAHLILDYINGGELFTHLSQHLHKLGIIYRDIKLENILLLTDFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1VZO, Chain A