1U59 Chain A
Tyrosine-protein kinase ZAP-70 (ZAP70)
Active — 100.0%DFG-inαC-inType1 · STU
Resolution
2.3 Å
R-value
0.217
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KKLFLKRDNLLIADIELGCGNFGSVRQGVYRKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGHHHHHH
UniProt reference sequence
LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA
Aligned reference sequence
LLIA--D-------------IELGCGN----------------FGSVRQGVY--RMRK----------------------------------KQIDVAIKVLK--QGTEKAD---------------------------TEEMMREAQIMHQL--------------------------DNPYIVRLIGVCQAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALMLVMEMAGG--------------GPLHKFLVG--KRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIPVSNVAELLHQVSMGMKYLEEK---------------------------------------------NFVHRDL-----AARNVLLVN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHYAKISDFGLSKALGADDSY--YTAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAGKWPLKWYAPECINF--------------------------------RKFS-SRSDVWSYGVTMWEALSY--G--------------QKPYKK--------------------------------------------------MKGPEVMAFIEQG--KRMECPPECP-----------------------------------------------------------------------------------------------------PELYALMSDCWIYKWEDRPD--------------FLTVEQRMRA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LLIA--D-------------IELGCGN----------------FGSVRQGVY--R-------------------------------------KQIDVAIKVLK--QGTEKAD---------------------------TEEMMREAQIMHQL--------------------------DNPYIVRLIGVCQAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALMLVMEMAGG--------------GPLHKFLVG--KRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIPVSNVAELLHQVSMGMKYLEEK---------------------------------------------NFVHRDL-----AARNVLLVN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHYAKISDFGLSKALGADDSY--YTAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAGKWPLKWYAPECINF--------------------------------RKFS-SRSDVWSYGVTMWEALSY--G--------------QKPYKK--------------------------------------------------MKGPEVMAFIEQG--KRMECPPECP-----------------------------------------------------------------------------------------------------PELYALMSDCWIYKWEDRPD--------------FLTVEQRMRA
Activation segment
DFGLSKALGADDSY--YTAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAGKWPLKWYAPE
Binding pocket
IELGCGNFGSVRQVAIKVLEMMREAQIMHQLDPYIVRLIGVMLVMEMAGGGPLHKFLVGYLEEKNFVHRDLAARNVLLISDFGLS
Ligand info
Orthosteric ligand
STU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1U59, Chain A