1MRY Chain A
RAC-beta serine/threonine-protein kinase (AKT2)
Inactive — 0.0%DFG-outαC-out
Resolution
2.8 Å
R-value
0.227
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms43
Missing residues6
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFD
UniProt reference sequence
FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
Aligned reference sequence
FDYL----------------KLLGKGT----------------FGKVILVRE--KA------------------------------------TGRYYAMKILR--KEVIIAKDE-------------------------VAHTVTESRVLQNT--------------------------RHPFLTALKYAFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFTEERARFYGAEIVSALEYLHSR---------------------------------------------DVVYRDI-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLCKEGISDGAT--M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTFCGTPEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHERLFELILME--EIRFPRTLS------------------------------------------------------------------------------------------------------PEAKSLLAGLLKKDPKQRLG--GGPSD-------AKEVMEHRFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDYL----------------KLLGKGT----------------FGKVILVRE--KA------------------------------------TGRYYAMKILR--KEVII-------------------------------------RVLQNT--------------------------RHPFLTALKYAFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFTEERARFYGAEIVSALEYLHSR---------------------------------------------DVVYRDI-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTPEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHERLFELILME--EIRFPRTLS------------------------------------------------------------------------------------------------------PEAKSLLAGLLKKDPKQRLG--GGPSD-------AKEVMEHRFF
Activation segment
DFGLC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTPEYLAPE
Binding pocket
KLLGKGTFGKVILYAMKIL______RVLQNTRPFLTALKYACFVMEYANGGELFFHLSRYLHSRDVVYRDIKLENLMLITDFGLC
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1MRY, Chain A