1KWP Chain A
MAP kinase-activated protein kinase 2 (MAPKAPK2)
Active — 63.3%DFG-inαC-in
Resolution
2.8 Å
R-value
0.233
Predicted activity confidence63.3%
Structure info
Alternate conformation—
Missing atoms26
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLK
UniProt reference sequence
YKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI
Aligned reference sequence
YKVT--S-------------QVLGLGI----------------NGKVLQIFN--KR------------------------------------TQEKFALKMLQ--D---------------------------------CPKARREVELHWRA--S-----------------------QCPHIVRIVDVYENLY--AGRK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLLIVMECLDG--------------GELFSRIQD--RGDQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTEREASEIMKSIGEAIQYLHSI---------------------------------------------NIAHRDV-----KPENLLYTS--KRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAILKLTDFGFAKETTSHNSL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTPCYTPYYVAPEVLGP--------------------------------EKYD-KSCDMWSLGVIMYILLCG-----------------YPPFYS--NHGL--------------------------------------------AISPGMKTRIRMG--QYEFPNPEWSEVS--------------------------------------------------------------------------------------------------EEVKMLIRNLLKTEPTQRMT--------------ITEFMNHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YKVT--S-------------QVLGLGI----------------NGKVLQIFN--KR------------------------------------TQEKFALKMLQ--D---------------------------------CPKARREVELHWRA--S-----------------------QCPHIVRIVDVYENLY--AGRK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLLIVMECLDG--------------GELFSRIQD--RGDQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTEREASEIMKSIGEAIQYLHSI---------------------------------------------NIAHRDV-----KPENLLYTS--KRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAILKLTDFGFAKETTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GP--------------------------------EKYD-KSCDMWSLGVIMYILLCG-----------------YPPFYS--NHGL--------------------------------------------AISPGMKTRIRM----YEFPNPEWSEVS--------------------------------------------------------------------------------------------------EEVKMLIRNLLKTEPTQRMT--------------ITEFMNHPWI
Activation segment
DFGFAKETTS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Binding pocket
QVLGLGINGKVLQFALKMLKARREVELHWRASPHIVRIVDVLIVMECLDGGELFSRIQDYLHSINIAHRDVKPENLLYLTDFGFA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1KWP, Chain A