1JPA Chain B
Ephrin type-B receptor 2 (EPHB2)
Inactive — 0.0%DFG-inαC-inATPlike · ANP
Resolution
1.91 Å
R-value
0.231
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KIFIDPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLK
UniProt reference sequence
VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDK
Aligned reference sequence
VKIE----------------QVIGAGE----------------FGEVCSGHL--KLPGK---------------------------------REIFVAIKTLK--SGYTEKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNVIHLEGVVTKST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEFMEN--------------GSLDSFLRQ--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLADM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRFLEDDTSD--PTYTSA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPIRWTAPEAIQY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MTNQDVINAIEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------SALHQLMLDCWQKDRNHRPK--------------FGQIVNTLDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VKIE----------------QVIGAGE----------------FGEVCSGHL------K---------------------------------REIFVAIKTLK--SGYTEKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNVIHLEGVVTKS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEFMEN--------------GSLDSFLRQ--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLADM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTAPEAIQY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MTN-DVINAIEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------SALHQLMLDCWQKDRNHRPK--------------FGQIVNTLDK
Activation segment
DF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTAPE
Binding pocket
QVIGAGEFGEVCSVAIKTLDFLSEASIMGQFDPNVIHLEGVMIITEFMENGSLDSFLRQYLADMNYVHRDLAARNILVVSDF___
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1JPA, Chain B