1I44 Chain A
Insulin receptor (INSR)
Inactive — 0.0%DFG-outαC-inATPlike · ACP
Resolution
2.4 Å
R-value
0.21
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK
UniProt reference sequence
ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD
Aligned reference sequence
ITLL----------------RELGQGS----------------FGMVYEGNA--RDIIKGE-------------------------------AETRVAVKTVN--ESASLRE---------------------------RIEFLNEASVMKGF--------------------------TCHHVVRLLGVVSKGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVVMELMAH--------------GDLKSYLRS--LRPEAENNPGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPTLQEMIQMAAEIADGMAYLNAK---------------------------------------------KFVHRDL-----AARNCMVAH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMTRDIYETDYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGLLPVRWMAPESLKD--------------------------------GVFT-TSSDMWSFGVVLWEITSL--A--------------EQPYQG--------------------------------------------------LSNEQVLKFVMDG--GYLDQPDNCP-----------------------------------------------------------------------------------------------------ERVTDLMRMCWQFNPKMRPT--------------FLEIVNLLKD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLL----------------RELGQGS----------------FGMVYEGNA--RDIIKGE-------------------------------AETRVAVKTVN--ESASLRE---------------------------RIEFLNEASVMKGF--------------------------TCHHVVRLLGVVSKGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVVMELMAH--------------GDLKSYLRS--LRPEAENNPGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPTLQEMIQMAAEIADGMAYLNAK---------------------------------------------KFVHRDL-----AARNCMVAH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVRWMAPESLKD--------------------------------GVFT-TSSDMWSFGVVLWEITSL--A--------------EQPYQG--------------------------------------------------LSNEQVLKFVMDG--GYLDQPDNCP-----------------------------------------------------------------------------------------------------ERVTDLMRMCWQFNPKMRPT--------------FLEIVNLLKD
Activation segment
DFGMT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVRWMAPE
Binding pocket
RELGQGSFGMVYEVAVKTVEFLNEASVMKGFT_HVVRLLGVLVVMELMAHGDLKSYLRSYLNAKKFVHRDLAARNCMVIGDFGMT
Ligand info
Orthosteric ligand
ACP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1I44, Chain A