1FVR Chain B
Angiopoietin-1 receptor (TEK)
Inactive — 0.2%DFG-outαC-out
Resolution
2.2 Å
R-value
0.195
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAE
UniProt reference sequence
IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR
Aligned reference sequence
IKFQ----------------DVIGEGN----------------FGQVLKARI--KKDG----------------------------------LRMDAAIKRMK--EYASKDD---------------------------HRDFAGELEVLCKL--G-----------------------HHPNIINLLGACEHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLAIEYAPH--------------GNLLDFLRK--SRVLETDPAFAIANSTAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSSQQLLHFAADVARGMDYLSQK---------------------------------------------QFIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYVAKIADFGLSRGQEVYVKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMGRLPVRWMAIESLNY--------------------------------SVYT-TNSDVWSYGVLLWEIVSL--G--------------GTPYCG--------------------------------------------------MTCAELYEKLPQG--YRLEKPLNCD-----------------------------------------------------------------------------------------------------DEVYDLMRQCWREKPYERPS--------------FAQILVSLNR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IKFQ----------------DVIGEGN----------------FGQVLKARI--KKDG----------------------------------LRMDAAIKRMK--EY---------------------------------RDFAGELEVLCKL--G-----------------------HHPNIINLLGACEHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLAIEYAPH--------------GNLLDFLRK--SRVLETDPAFAIANSTAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSSQQLLHFAADVARGMDYLSQK---------------------------------------------QFIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYVAKIADFGLSRGQEVYVKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLPVRWMAIESLNY--------------------------------SVYT-TNSDVWSYGVLLWEIVSL--G--------------GTPYCG--------------------------------------------------MTCAELYEKLPQG--YRLEKPLNCD-----------------------------------------------------------------------------------------------------DEVYDLMRQCWREKPYERPS--------------FAQILVSLNR
Activation segment
DFGLSRGQEVYVKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLPVRWMAIE
Binding pocket
DVIGEGNFGQVLKAAIKRMDFAGELEVLCKLGPNIINLLGAYLAIEYAPHGNLLDFLRKYLSQKQFIHRDLAARNILVIADFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1FVR, Chain B