1BYG Chain A
Tyrosine-protein kinase CSK (CSK)
Inactive — 0.1%DFG-outαC-outType1 · STU
Resolution
2.4 Å
R-value
0.199
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDAQAFLAEASVMTQLRHSNLVQLLGVIVEEGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHEL
UniProt reference sequence
LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEH
Aligned reference sequence
LKLL----------------QTIGKGE----------------FGDVMLGDY----------------------------------------RGNKVAVKCIK--NDAT------------------------------AQAFLAEASVMTQL--------------------------RHSNLVQLLGVIVEEK--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLYIVTEYMAK--------------GSLVDYLRS--RGRS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGGDCLLKFSLDVCEAMEYLEGN---------------------------------------------NFVHRDL-----AARNVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVAKVSDFGLTKEASSTQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTGKLPVKWTAPEALRE--------------------------------KKFS-TKSDVWSFGILLWEIYSF--G--------------RVPYPR--------------------------------------------------IPLKDVVPRVEKG--YKMDAPDGCP-----------------------------------------------------------------------------------------------------PAVYEVMKNCWHLDAAMRPS--------------FLQLREQLEH
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKLL----------------QTIGKGE----------------FGDVMLGDY----------------------------------------RGNKVAVKCIK--ND--------------------------------AQAFLAEASVMTQL--------------------------RHSNLVQLLGVIVEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLYIVTEYMAK--------------GSLVDYLRS--RGRS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGGDCLLKFSLDVCEAMEYLEGN---------------------------------------------NFVHRDL-----AARNVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVAKVSDFGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVKWTAPEALRE--------------------------------KKFS-TKSDVWSFGILLWEIYSF--G--------------RVPYPR--------------------------------------------------IPLKDVVPRVEKG--YKMDAPDGCP-----------------------------------------------------------------------------------------------------PAVYEVMKNCWHLDAAMRPS--------------FLQLREQLEH
Activation segment
DFGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVKWTAPE
Binding pocket
QTIGKGEFGDVMLVAVKCIAFLAEASVMTQLRSNLVQLLGVYIVTEYMAKGSLVDYLRSYLEGNNFVHRDLAARNVLVVSDFGL_
Ligand info
Orthosteric ligand
STU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1BYG, Chain A