1BLX Chain A
Cyclin-dependent kinase 6 (CDK6)
Inactive — 0.3%DFG-inαC-out
Resolution
1.9 Å
R-value
0.2
Predicted activity confidence0.3%
Structure info
Alternate conformation—
Missing atoms2
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKEN
UniProt reference sequence
YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
Aligned reference sequence
YECV----------------AEIGEGA----------------YGKVFKARD--LKN-----------------------------------GGRFVALKRVR--VQTGEEGM--------------------------PLSTIREVAVLRHL--ETF---------------------EHPNVVRLFDVCTVSR--TDRET-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTLVFEHVD---------------QDLTTYLDK--VPEP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPTETIKDMMFQLLRGLDFLHSH---------------------------------------------RVVHRDL-----KPQNILVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQIKLADFGLARIYSFQMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSVVVTLWYRAPEVLLQ--------------------------------SSYA-TPVDLWSVGCIFAEMFRR-----------------KPLFRG--------------------------------------------------SSDVDQLGKILDV--IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDID---------------------------------------------------------------------------ELGKDLLLKCLTFNPAKRIS--------------AYSALSHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YECV----------------AEIGEGA----------------YGKVFKARD--LKN-----------------------------------GGRFVALKRVR--VQTGEEGM--------------------------PLSTIREVAVLRHL--ETF---------------------EHPNVVRLFDVCTVSR--TDRET-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTLVFEHVD---------------QDLTTYLDK--VPEP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPTETIKDMMFQLLRGLDFLHSH---------------------------------------------RVVHRDL-----KPQNILVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQIKLADFGLARIYSFQMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSVVVTLWYRAPEVLLQ--------------------------------SSYA-TPVDLWSVGCIFAEMFRR-----------------KPLFRG--------------------------------------------------SSDVDQLGKILDV--IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDID---------------------------------------------------------------------------ELGKDLLLKCLTFNPAKRIS--------------AYSALSHPYF
Activation segment
DFGLARIYSFQMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSVVVTLWYRAPE
Binding pocket
AEIGEGAYGKVFKVALKRVSTIREVAVLRHLEPNVVRLFDVTLVFEHVD_QDLTTYLDKFLHSHRVVHRDLKPQNILVLADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 1BLX, Chain A